Stability of new carbapenem DA-1131 to renal dipeptidase (dehydropeptidase I).

نویسندگان

  • Sung Wook Park
  • Jeoung Soon We
  • Gye Won Kim
  • Seong Hak Choi
  • Haeng Soon Park
چکیده

The stability of DA-1131 to renal dipeptidase (RDPase) (EC 3.4.13.19) was compared with that of imipenem and meropenem by V(max)/K(m) ratios as an index of the enzyme's preference for substrates. Our results showed a decreasing order of imipenem (6.24), meropenem (2.41), and DA-1131 (1.39). The biochemical evaluation of DA-1131 as the least preferred substrate of RDPase suggests its potential use as a novel beta-lactam antibiotic which may be usable without coadministration of RDPase inhibitors once its clinical suitability is proven.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 46 2  شماره 

صفحات  -

تاریخ انتشار 2002